Search
Author
Title
Vol.
Issue
Year
1st Page

Journal of Animal Science Abstract - Molecular Genetics

BOARD-INVITED REVIEW: Applications of genomic information in livestock12

 

This article in

  1. Vol. 85 No. 12, p. 3148-3158
     
    Received: May 21, 2007
    Accepted: Aug 13, 2007
    Published: December 8, 2014


    3 Corresponding author(s): taylorjerr@missouri.edu
 View
 Download
 Share

doi:10.2527/jas.2007-0291
  1. E. M. Sellner*,
  2. J. W. Kim*,
  3. M. C. McClure*,
  4. K. H. Taylor,
  5. R. D. Schnabel* and
  6. J. F. Taylor*3
  1. Division of Animal Sciences, University of Missouri, Columbia 65211;
    Pathology and Anatomical Sciences, University of Missouri, Columbia 65212

Abstract

The availability of whole genome sequences for individual species will change the landscape for livestock genomic research. Animal scientists will have access to whole-genome sequence-based technologies such as high-throughput SNP genotyping assays, gene expression profiling, methylation profiling, RNA interference, and genome resequencing that will revolutionize the scale upon which research will be conducted. These technologies will also alter the ways we think about addressing industry and scientific problems. In this review, we discuss the scientific bases for these emerging technologies and present recent highlights of their application in human, model species, and livestock as well as their potential for future applications in livestock. Additionally, we discuss strategies for their use in the genetic improvement and management of livestock. In particular, we present a strategy for the simultaneous identification of causal mutations underlying phenotypic traits in livestock and discuss issues that will arise in the application of whole genome selection for the prediction of genetic merit in livestock. We also point out that the statistical analysis that underlies the whole genome selection methodology is a sophisticated enhancement of single marker association mapping analysis to allow the entire genome to be simultaneously analyzed.

Copyright © 2007. Copyright 2007 Journal of Animal Science