1st Page



This article in

  1. Vol. 86 No. 10, p. 2797-2805
    unlockOPEN ACCESS
    Received: Apr 08, 2008
    Accepted: June 09, 2008
    Published: February 9, 2015

    2 Corresponding author(s):


A commentary on domestic animals as dual-purpose models that benefit agricultural and biomedical research1

  1. J. J. Ireland*2,
  2. R. M. Roberts,
  3. G. H. Palmer,
  4. D. E. Bauman§ and
  5. F. W. Bazer#
  1. Department of Animal Science, Michigan State University, East Lansing 48824-1225;
    Department of Animal Science, University of Missouri, Columbia 65211-7310;
    Department of Veterinary Microbiology and Pathology, and School for Global Animal Health, Washington State University, Pullman 99164-7040;
    Department of Animal Science, Cornell University, Ithaca, NY 14853-4801; and
    Department of Animal Science, Texas A&M University, College Station 77843-2471


Research on domestic animals (cattle, swine, sheep, goats, poultry, horses, and aquatic species) at land grant institutions is integral to improving the global competitiveness of US animal agriculture and to resolving complex animal and human diseases. However, dwindling federal and state budgets, years of stagnant funding from USDA for the Competitive State Research, Education, and Extension Service National Research Initiative (CSREES-NRI) Competitive Grants Program, significant reductions in farm animal species and in numbers at land grant institutions, and declining enrollment for graduate studies in animal science are diminishing the resources necessary to conduct research on domestic species. Consequently, recruitment of scientists who use such models to conduct research relevant to animal agriculture and biomedicine at land grant institutions is in jeopardy. Concerned stakeholders have addressed this critical problem by conducting workshops, holding a series of meetings with USDA and National Institutes of Health (NIH) officials, and developing a white paper to propose solutions to obstacles impeding the use of domestic species as dual-purpose animal models for high-priority problems common to agriculture and biomedicine. In addition to shortfalls in research support and human resources, overwhelming use of mouse models in biomedicine, lack of advocacy from university administrators, long-standing cultural barriers between agriculture and human medicine, inadequate grantsmanship by animal scientists, and a scarcity of key reagents and resources are major roadblocks to progress. Solutions will require a large financial enhancement of USDA’s Competitive Grants Program, educational programs geared toward explaining how research using agricultural animals benefits both animal agriculture and human health, and the development of a new mind-set in land grant institutions that fosters greater cooperation among basic and applied researchers. Recruitment of outstanding scientists dedicated to using domestic animal models for agricultural and biomedical research, strong incentives for scientists to take advantage of training opportunities to write NIH grants, and greater NIH and USDA cooperation to sponsor the use of agricultural animals as dual-purpose animal models that benefit agriculture and biomedicine will also be necessary. In conclusion, the broad diversity of animal models needed for agricultural and biomedical research is at risk unless research priorities at the land grant universities are critically evaluated and financial support for such research is dramatically increased.

Copyright © 2008. Copyright 2008 Journal of Animal Science