1st Page



This article in JAS

  1. Vol. 88 No. 7, p. 2530-2539
    Received: Jan 21, 2010
    Published: December 4, 2014

    1 Corresponding author(s):


Precision genetics for complex objectives in animal agriculture

  1. S. C. Fahrenkrug 1,
  2. A. Blake#,
  3. D. F. Carlson*†‡,
  4. T. Doran,
  5. A. Van Eenennaam,
  6. D. Faber**,
  7. C. Galli††,
  8. Q. Gao‡‡,
  9. P. B. Hackett†§§,
  10. N. Li##,
  11. E. A. Maga‖‖,
  12. W. M. Muir¶¶,
  13. J. D. Murray¶***,
  14. D. Shi§,
  15. R. Stotish***,
  16. E. Sullivan†††,
  17. J. F. Taylor‡‡‡,
  18. M. Walton§§§,
  19. M. Wheeler###,
  20. B. Whitelaw‖‖‖ and
  21. B. P. Glenn¶¶¶
  1. Department of Animal Science, University of Minnesota, St. Paul 55108;
    Center for Genome Engineering, University of Minnesota, Minneapolis 55455;
    Recombinetics Inc., Minneapolis, MN 55418;
    Animal Reproduction Institute, Guangxi University, Nanning, P.R. China 530000;
    Yorktown Technologies, Austin, TX 78750;
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220 Australia;
    Department of Animal Science, University of California, Davis 95616;
    Trans Ova Genetics, Sioux Center, IA 51250;
    Laboratorio di Tecnologie della Riproduzione, Instituto Sperimentale Italiano Lazzaro Spallanzani, Cremona, Italy 26100;
    Jiangsu Animal Husbandry and Veterinary College, Taizhou, P.R. China 225300;
    Department of Genetics and Cell Biology, University of Minnesota, Minneapolis 55455;
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, P.R. China 100094;
    Department of Animal Science, Purdue University, West Lafayette, IN 47907;
    Department of Population Health and Reproduction, University of California, Davis 95616;
    Aqua Bounty Technologies, Waltham, MA 02451;
    Hematech Inc., Sioux Falls, SD 57104;
    Division of Animal Sciences, University of Missouri, Columbia, MO 65201;
    ViaGen Inc., Austin, TX 78727;
    Department of Animal Sciences, University of Illinois, Urbana-Champaign 61801;
    The Roslin Institute, The University of Edinburgh, Roslin, Midlothian EH25 9PS Scotland, UK; and
    Biotechnology Industry Organization, Washington, DC 20024



Indirect modification of animal genomes by interspecific hybridization, cross-breeding, and selection has produced an enormous spectrum of phenotypic diversity over more than 10,000 yr of animal domestication. Using these established technologies, the farming community has successfully increased the yield and efficiency of production in most agricultural species while utilizing land resources that are often unsuitable for other agricultural purposes. Moving forward, animal well-being and agricultural sustainability are moral and economic priorities of consumers and producers alike. Therefore, these considerations will be included in any strategy designed to meet the challenges produced by global climate change and an expanding world population. Improvements in the efficiency and precision of genetic technologies will enable a timely response to meet the multifaceted food requirements of a rapidly increasing world population.

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Copyright © 2010. American Society of Animal Science