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This article in JAS

  1. Vol. 89 No. 1, p. 168-178
     
    Received: Mar 11, 2010
    Accepted: Sept 17, 2010
    Published: December 4, 2014


    3 Corresponding author(s): loerch.1@osu.edu
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doi:10.2527/jas.2010-2976

Effect of feeding fat or intrajugular infusion of glucagon-like peptide-1 and cholecystokinin on dry matter intake, digestibility, and digesta rate of passage in growing wethers1

  1. A. E. Relling*†22,
  2. C. K. Reynolds and
  3. S. C. Loerch 3
  1. Ohio State University Interdisciplinary Nutrition Program (OSUN), and
    Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center, 1680 Madison Ave., Wooster 44691-4096; and
    School of Agriculture, Policy and Development, University of Reading, Earley Gate, Reading RG6 6AR, United Kingdom

ABSTRACT

ABSTRACT

A cause and effect relationship between glucagon-like peptide 1 (7, 36) amide (GLP-1) and cholecystokinin (CCK) and DMI regulation has not been established in ruminants. Three randomized complete block experiments were conducted to determine the effect of feeding fat or infusing GLP-1 or CCK intravenously on DMI, nutrient digestibility, and Cr rate of passage (using Cr2O3 as a marker) in wethers. A total of 18 Targhee × Hampshire wethers (36.5 ± 2.5 kg of BW) were used, and each experiment consisted of four 21-d periods (14 d for adaptation and 7 d for infusion and sampling). Wethers allotted to the control treatments served as the controls for all 3 experiments; experiments were performed simultaneously. The basal diet was 60% concentrate and 40% forage. In Exp. 1, treatments were the control (0% added fat) and addition of 4 or 6% Ca salts of palm oil fatty acids (DM basis). Treatments in Exp. 2 and 3 were the control and 3 jugular vein infusion dosages of GLP-1 (0.052, 0.103, or 0.155 µg∙kg of BW−1∙d−1) or CCK (0.069, 0.138, or 0.207 µg∙kg of BW−1∙d−1), respectively. Increases in plasma GLP-1 and CCK concentrations during hormone infusions were comparable with increases observed when increasing amounts of fat were fed. Feeding fat and infusion of GLP-1 tended (linear, P = 0.12; quadratic, P = 0.13) to decrease DMI. Infusion of CCK did not affect (P > 0.21) DMI. Retention time of Cr in the total gastrointestinal tract decreased (linear, P < 0.01) when fat was fed, but was not affected by GLP-1 or CCK infusion. In conclusion, jugular vein infusion produced similar plasma CCK and GLP-1 concentrations as observed when fat was fed. The effects of feeding fat on DMI may be partially regulated by plasma concentration of GLP-1, but are not likely due solely to changes in a single hormone concentration.

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