Search
Author
Title
Vol.
Issue
Year
1st Page

Abstract

 

This article in JAS

  1. Vol. 90 No. 9, p. 3135-3142
     
    Received: Nov 25, 2011
    Published: January 20, 2015


    2 Corresponding author(s): jaap.vanmilgen@rennes.inra.fr
 View
 Download
 Share

doi:10.2527/jas.2011-4956

Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigs1

  1. M. Gloaguen*†‡,
  2. N. Le Floc’h*†,
  3. E. Corrent,
  4. Y. Primot and
  5. J. van Milgen 2
  1. *INRA, UMR1348 PEGASE, F-35590 Rennes, France
    †Agrocampus Ouest, UMR1348 PEGASE, F-35000 Rennes, France
    ‡AJINOMOTO EUROLYSINE S.A.S., F-75817 Paris Cedex 17, France

Abstract

Indispensable AA are involved in the control of feed intake. When a diet deficient in Val is offered to pigs, feed intake is typically reduced. This effect is aggravated when dietary Leu is supplied in excess of the requirement. If an unbalanced supply of branched-chain AA (BCAA) is harmful, an anorectic response may serve as a mechanism to prevent this situation. We verified this hypothesis by measuring the voluntary feed intake of a balanced diet offered during the 30-min period 1 h after ingestion of a test meal deficient or not in Val (Val- and Val+) with an excess of Leu. Twelve and four 6-wk-old crossbred female pigs were used in Exp. 1 and 2, respectively. Prior ingestion of the Val- test meal resulted in a 14% reduction in feed intake compared with that observed after ingestion of the Val+ test meal (P = 0.06) in Exp. 1, indicating that the signal to reduce feed intake occurred within 1 h. It is possible that the plasma concentration of the limiting AA serves as a signal for the dietary AA deficiency. We therefore determined the postprandial plasma concentrations of BCAA and their α-keto acids after ingestion of Val- and Val+ in 4 pigs in Exp. 2. After ingestion of the Val- diet, plasma concentrations of Val and its keto acid were reduced compared with values observed after ingestion of the Val+ diet. The peak concentration occurred earlier after ingestion of the Val- diet compared with that of the Val+ diet. Although the plasma concentration increased after the meal, it declined rapidly in pigs offered Val-, and the Val concentration 4 h after ingestion of the meal was even less than that observed in the fasted state. In conclusion, it appears that the pig is able to detect a deficient supply of Val within 1 h after ingestion. The plasma concentration of Val or its concentration relative to the other BCAA during the postprandial period may act as a signal indicating the AA deficiency.

  Please view the pdf by using the Full Text (PDF) link under 'View' to the left.

Copyright © 2012. American Society of Animal Science