1st Page



This article in JAS

  1. Vol. 91 No. 1, p. 268-275
    Received: Mar 30, 2012
    Accepted: Sept 13, 2012
    Published: December 3, 2014

    2 Corresponding author(s):


Astaxanthin modulates age-associated mitochondrial dysfunction in healthy dogs1

  1. J. S. Park*,
  2. B. D. Mathison*,
  3. M. G. Hayek,
  4. J. Zhang,
  5. G. A. Reinhart and
  6. B. P. Chew 2
  1. Washington State University, Pullman 99164
    P&G Pet Care, Lewisburg, OH 45338


Young (2.97 ± 0.01 yr; 8.16 ± 0.15 kg BW) and geriatric (10.71 ± 0.01 yr; 9.46 ± 0.18 kg BW) healthy female Beagle dogs (n = 14/age group) were fed 0 or 20 mg astaxanthin daily for 16 wk to examine modulation of mitochondrial function. Fasted blood was sampled on wk 0, 8, and 16. Mitochondria membrane permeability, ATP production, cytochrome c oxidase/reductase, and number were assessed in leukocytes whereas astaxanthin uptake, glutathione, superoxide dismutase, nitric oxide, 8-hydroxy-2’-deoxyguanosine, 8-isoprostane, and protein carbonyl were measured in plasma. Aging increased (P < 0.05) complex III cytochrome c oxidoreductase but decreased (P < 0.05) 8-hydroxy-2’-deoxyguanosine and protein carbonyl. Mitochondrial function improved in both young and geriatric dogs by increasing (P < 0.05) ATP production, mitochondria mass, and cytochrome c oxidoreductase activity, especially in geriatric dogs compared with young dogs. Astaxanthin feeding also increased (P < 0.05) the reduced glutathione to oxidized glutathione ratio in young dogs and decreased (P < 0.05) nitric oxide in both young and geriatric dogs. Dietary astaxanthin improved mitochondrial function in blood leukocytes, most likely by alleviating oxidative damage to cellular DNA and protein.

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