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Journal of Animal Science Abstract - Animal Genetics

Identification of single nucleotide polymorphisms in genes involved in digestive and metabolic processes associated with feed efficiency and performance traits in beef cattle12

 

This article in JAS

  1. Vol. 91 No. 6, p. 2512-2529
     
    Received: Aug 15, 2012
    Accepted: Mar 07, 2013
    Published: November 25, 2014


    3 Corresponding author(s): miller@uoguelph.ca
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doi:10.2527/jas.2012-5756
  1. M. K. Abo-Ismail*†,
  2. M. J. Kelly*‡,
  3. E. J. Squires*,
  4. K. C. Swanson,
  5. S. Bauck# and
  6. S. P. Miller 3
  1. Centre for Genetic Improvement of Livestock, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada, N1G 2W0
    Department of Animal and Poultry Science, Damanhour University, Damanhour, Egypt
    Queensland Alliance for Agriculture and Food Innovation University of Queensland, St Lucia, QLD 4072, Australia
    Animal Sciences Department, North Dakota State University, Fargo 58108-6050
    GeneSeek, 4665 Innovation Drive, Suite 120, Lincoln, NE 68521

Abstract

Discovery of genetic mutations that have a significant association with economically important traits would benefit beef cattle breeders. Objectives were to identify with an in silico approach new SNP in 8 genes involved in digestive function and metabolic processes and to examine the associations between the identified SNP and feed efficiency and performance traits. The association between SNP and daily DMI, ADG, midpoint metabolic weight (MMWT), residual feed intake (RFI), and feed conversion ratio (FCR; the ratio of average daily DMI to ADG) was tested in discovery and validation populations using a univariate mixed-inheritance animal model fitted in ASReml. Substitution effect of the T allele of SNP rs41256901 in protease, serine, 2 (trypsin 2; PRSS2) was associated with FCR (–0.293 ± 0.08 kg DMI kg–1 BW gain; P < 0.001) and RFI (–0.199 ± 0.08 kg; P < 0.01) and although not significant in the validation population, the phase of association remained. In the cholecystokinin B receptor (CCKBR) gene, genotypes in rs42670351 were associated with RFI (P < 0.05) whereas genotypes in rs42670352 were associated with RFI (P = 0.002) and DMI (P < 0.05). Substitution of the G allele in rs42670352 was associated with DMI (–0.236 ± 0.12 kg; P = 0.055) and RFI (–0.175 ± 0.09 kg; P = 0.05). Substitution of the G allele of SNP rs42670353 was associated with ADG (0.043 ± 0.02 kg/d; P < 0.01) and FCR (0.114 ± 0.05 kg BW gain kg–1 DMI; P < 0.05). In the validation dataset, SNP rs42670352 in gene CCKBR was significant for RFI and DMI and had the same phase of associations; SNP rs42670353 was significantly associated with FCR with same phase of association and the C allele in SNP rs42670351 was validated as decreasing DMI, RFI, and FCR. Substituting the G allele of SNP rs42670352 in CCKBR2 was associated with decreasing DMI and RFI in the validation study. New SNP were reported in genes PRSS2 and CCKBR, being associated with feed efficiency and performance traits in beef cattle. The association between these SNP with fertility, carcass, and meat quality traits must still be tested.

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