The angiotensin-bradykinin pathways. Angiotensin-converting enzyme (ACE) plays are role in the regulation of the bradykinin and angiotensin pathways. Bradykinin can elicit vasodilation by increasing endothelial derived hyperpolarizing factors (EDHF), prostacyclin (PGI2), or nitric oxide (NO). Angiotensin II will cause vasoconstriction. However, if angiotensin II is further converted to angiotensin 1-7, vasodilation could occur via NO and PGI2.